Protagonists: Sam, Dean, Castiel, John Winchester, Mary Winchester
Major Antagonists: Anna, Uriel, Michael
FEATURED CREATURES: Angel
Over Plot: The guys try to stop Lucifer and prevent Armageddon
Major Character Deaths: Anna, Sam
Minor Deaths: mechanic
Notes: Anna turns antagonist when she decides that Sam has to die, Anna kills Sam, first appearance of Michael, Michael possesses John to heal him and then kills Anna, heals Sam and sends them back to their time. Anna as far as I can tell is the only instance, at least thus far, that an angel has their own form, so no host death.
Episode Bystander Kill Count: 1 human
Killed/Destroyed/Banished Count: 0